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KMID : 1149220200280020137
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Korean Journal of Oriental Medical Prescription
2020 Volume.28 No. 2 p.137 ~ p.145
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Antioxidant and Anti-inflammatory Activities of Tetragonia tetragonoides Water Extract
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Kong Ji-Hyun
Lee Ki-Yeon
Rho Dae-Hyun
Lee Jang-Cheon
An Won-Gun
Lee Boo-Kyun
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Abstract
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Objectives : Tetragonia tetragonioides is one of the traditional herbal medicines that can be used to protect the stomach and treat cancer. However, its mechanism of overcoming gastrointestinal disorders is unclear. In this study, we investigated antioxidant and anti-inflammatory effects of Tetragonia tetragonioides Water Extract (TTWE) on RAW264.7 cells.
Methods : The cell viability by TTWE was measured by using MTT assay. The free radical scavenging ability and cytokine production were analyzed by using ELISA Kit. SPSS version 25 was used for statistical analysis.
Results : According to the results of this study, the cell viability measurement of TTWE significantly affected the cell viability. The radical scavenging ability of TTWE showed the highest effect compared to the positive control group when the concentration was 3.1-12.5 μg/ml, and significantly inhibited NO production induced by LPS. In addition, the inhibitory effect of TTWE on the production of IL-6 and TNF-α induced by LPS was significant at both TTWE concentrations of 12.5 μg/ml [p <0.01 (IL-6), p <0.05 (TNF-α)].
Conclusion : In conclusion, it is suggested that the antioxidant function of Tetragonia tetragonioides Water Extract could be used to prevent and treat inflammatory diseases.
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KEYWORD
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Tetragonia tetragonioides, antioxidant, anti-inflammatory, RAW264.7
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